Genes and asymptomatic forms, from which variant one became infected, more defenses

Genes and asymptomatic forms, from which variant one became infected, more defenses
from Laura Della EasterLaura Della Easter

1. Are genes responsible for the asymptomatic forms?

2. Is it possible to find out what type of variant you are infected with?

3. Are you more vulnerable to the flu with three vaccines and a sluggish immune system?

1. Are genes responsible for the asymptomatic forms?

The discovery is Italian. A team of researchers from the Ceinge-Biotechnology of Naples directed by Mario Capasso And Achille Iolascon, both professors of Medical Genetics at the Federico II University of Naples, gave an answer to why some people contract Covid asymptomatically, despite having risk factors such as old age. The study published in the journal Genetics in Medicinenotes that at least asymptomatic cases are at the origin three rare genetic mutations which act by weakening the genes involved in the activation processes of the immune system. “Today it is amply demonstrated that theexcessive immune response to SarsCoV2 infection and the subsequent hyper-activation of pro-inflammatory and pro-coagulation processes are the root cause of organ damage such as lungs, heart, kidney, “observes Capasso, and” our research shows that mutations in the human genome that attenuate this excessive immune reaction can predispose to infection without severe symptoms. “

Rare pathogenetic mutations were also identified that were significantly more frequent in infected and asymptomatic and non-infected subjects, in a large series of approximately 57,000 healthy subjects. The discovery is destined to have numerous applications and the researchers have made available, in an online database, all the genetic data obtained, so that they can be consulted by researchers around the world. Achille Iolascon explained that “these mutations can be used to identify individuals who are predisposed to developing less severe or asymptomatic forms of Covid-19 disease. Furthermore, the serum levels of the three identified genes could be used as prognostic markers of severe disease. Finally, today we know something more about the biological basis of this disease and therefore we have something to work on to develop new pharmacological treatments ”.

2. Is it possible to find out what type of variant you are infected with?

Omicron is rapidly changing and the question that sufferers are asking is whether it is possible to recognize the virus’s sub-lineage. We turned the question over to the virologist Maria Chironnaprofessor at the University of Bari and head of the Covid analysis laboratory at the Polyclinic.

Establishing with certainty which specific variant one has been infected with is only possible with the use of advanced molecular techniques such as sequencing the entire viral genome. Sequencing takes time. Therefore, there are gods faster molecular tests that allow you to do a first screening and then “suspect” a certain variant.

Does anything change in the therapeutic treatment if the variant is known?

It is not necessary to perform a routine test to know which variant you have been infected with because the clinical management does not change. In addition, variant detection is very expensive and it is done for epidemiological purposes, only in a selected sample of patients from the population, in order to assess the proportion of their circulation. When a variant becomes predominant it is assumed that practically all cases are due to that variant. The continuous monitoring of the variants on the population has the value of Public Health and also serves to intercept new ones, should they emerge. And its diffusion follows with periodic surveys. At the moment in Italy over 90% of cases are attributable to Omicron 2.

3. Are you more vulnerable to the flu with three vaccines and a sluggish immune system?

Perhaps it may be that the safety measures have been loosened, that the mask is worn very little, that we have returned to hug each other, but also the flu virusafter two years of arrest, started to circulate again. Some readers have asked if it is also due to a sluggish immune system due to the three anti Covid vaccines. Here is what the virologist replies Maria Chironna. “The three doses of the anti Covid-19 vaccine (2 doses + the booster or booster) do not” lazy “the immune system at all and do not make us more vulnerable. Many vaccinations are recommended throughout life, some of which are carried out by administering multiple doses to ensure maximum protection, as in the case of vaccination against Covid19. The immune system is “trained” to respond adequately to multiple antigenic stimuli. Unfortunately, there are no vaccines against all possible viruses cause of respiratory diseases. And that’s why we can get sick anyway. On the other hand, there are effective vaccines against influenza caused by influenza viruses (A and B) not to be confused with other agents (parainfluenza virus, rhinovirus, adenovirus, respiratory syncytial virus, other human coronaviruses, etc.) which can cause symptoms that are partly overlapping. to those of the flu and against which there are no vaccines yet “.

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